David G. Brown, Ph.D.
Chief Scientist, Emeritus DIAM/FDA
The course will cover the broad range of performance metrics that go beyond the simple calculation of success rate or accuracy on a limited test set. These include sensitivity, specificity, positive and negative predictive value, receiver operating characteristic (ROC) curve, and area under the ROC curve (AUC). Particular attention will be paid to the ROC curve formalism, and a hands-on demonstration will be given. Participants will be asked to bring a laptop or other computational device and will take part in simulated reader studies to better understand ROC methodology and to compete for prizes. Both parametric and nonparametric uncertainty calculation techniques will be discussed, and the importance of good data hygiene in maintaining complete separation of training and test data will be illustrated.
David Brown is recently retired from a 40 year career in medical imaging and CAD performance assessment methodology research at the U.S. Food and Drug Administration. He is an SPIE fellow and member of the college of fellows of the International Neural Network Society, of which he was a long time Board member and former President.
Frank Samuelson received his Ph.D. in Astrophysics from Iowa State University, and was a post-doctoral fellow at the Los Alamos National Laboratory. Since 2004 he has worked for the US Food and Drug Administration in the evaluation of imaging devices.